Description

Cytochalasin CAS NO 36084-18-1 is a potent cell-permeable mycotoxin that acts as a specific inhibitor of actin polymerization, disrupting microfilament organization and dynamics. This mechanism makes it an indispensable research tool for studying cytoskeletal function, cell motility, and cytokinesis. It is primarily utilized by life science researchers, pharmaceutical developers, and academic institutions engaged in cell biology, cancer research, and drug discovery programs.

Application

• Cell Biology Research: Used to study actin filament dynamics, cell motility, membrane ruffling, and phagocytosis.
• Cancer Research: Investigated for its effects on tumor cell invasion, metastasis, and angiogenesis by disrupting the cytoskeleton.
• Developmental Biology: Employed to inhibit cytokinesis and study cell division processes in embryos and cultured cells.
• Pharmacology & Toxicology: Serves as a reference toxin and a tool compound for screening cytoprotective agents or studying mycotoxin effects.
• Drug Discovery: Used in target validation and phenotypic screening assays where cytoskeletal disruption is a desired or measured endpoint.
• Virology: Applied in studies examining viral entry, replication, and spread, which often depend on host cell actin networks.

Basic Information

Product Name	Cytochalasin
CAS No.	36084-18-1
Molecular Formula	C29H37NO5
Molecular Weight	479.61 g/mol
Synonyms	Cytochalasin B; Phomin; NSC 209801; (3S,5S,7S,8S,11S,13S,15R,16R)-16-Benzyl-3-benzyloxy-5,7,11,15-tetrahydroxy-8,13,15-trimethyl-1-oxa-4-azacyclohexadecane-2,6,12,16-tetrone; 7-Benzyl-13-benzyloxy-1,3,5,11-tetrahydroxy-9,15-dimethyl-10-oxa-4-azatricyclo[10.3.1.03,5]hexadecane-2,6,12,14-tetrone
EINECS	Contact for details

Quality Control

Our Cytochalasin is produced and tested under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analysis, including identity confirmation, purity assessment, and biological activity verification. A Certificate of Analysis (COA) detailing specifications such as purity (by HPLC), identity (by IR/MS), and biological potency is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Biological Activity	Inhibits actin polymerization (IC50 typically 1-5 µM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.