Description

3-(2-(2-(2-Idoacetamido)Ethoxy)Ethylcarbamoyl)-2,2,5,5-Tetra Methyl-1-Pyrrolidinyloxy is a specialized nitroxide spin label compound, also known as a maleimide-TEMPO derivative. This product is a critical tool for probing protein structure, dynamics, and interactions using Electron Paramagnetic Resonance (EPR) spectroscopy. It is primarily utilized by research scientists and process developers in the fields of structural biology, biophysics, and pharmaceutical development for site-directed spin labeling (SDSL) studies.

Application

• Site-Directed Spin Labeling (SDSL): Covalently attaches to cysteine residues in proteins for EPR-based structural analysis.
• Protein Conformation Studies: Used to investigate protein folding, unfolding, and conformational changes in solution.
• Membrane Protein Research: Aids in studying the structure and dynamics of challenging membrane-bound protein targets.
• Protein-Protein Interaction Mapping: Helps determine distances and orientations between labeled sites to map interaction interfaces.
• Drug Discovery & Biologics Development: Employed in characterizing therapeutic proteins, antibodies, and other biologics to support formulation and stability studies.
• Academic & Industrial R&D: Serves as a key reagent in fundamental biochemical research and applied biotechnological development.

Basic Information

Product Name	3-(2-(2-(2-Idoacetamido)Ethoxy)Ethylcarbamoyl)-2,2,5,5-Tetra Methyl-1-Pyrrolidinyloxy
CAS No.	36034-66-9
Molecular Formula	C18H30IN3O5
Molecular Weight	495.35 g/mol
Synonyms	Maleimide-TEMPO; 3-Maleimido-PROXYL; 3-Maleimido-2,2,5,5-tetramethyl-1-pyrrolidinyloxy; MTSSL (Maleimide-TEMPO Spin Label); 1-Oxyl-2,2,5,5-tetramethylpyrroline-3-carboxamidoethylmaleimide; N-(1-Oxyl-2,2,5,5-tetramethyl-3-pyrrolidinyl)maleimide; Iodoacetamide-TEMPO derivative; PROXYL maleimide spin label
EINECS	Contact for details

Quality Control

Our 3-(2-(2-(2-Idoacetamido)Ethoxy)Ethylcarbamoyl)-2,2,5,5-Tetra Methyl-1-Pyrrolidinyloxy is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to support our global customer base in regulated and non-regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under anhydrous conditions, such as in a desiccator, to maintain stability and purity. For long-term storage, consider storing at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Spin Concentration (EPR)	≥ 90% active
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.