Description

Cytochalasin E is a potent secondary metabolite and mycotoxin belonging to the cytochalasin family, known for its specific biological activity as an inhibitor of actin polymerization. This makes it a critical research tool for studying cytoskeletal dynamics, cell motility, and morphology in various biological systems. It is primarily utilized by researchers and scientists in the fields of cell biology, pharmacology, and toxicology for in vitro studies and biochemical research.

Application

• Cytoskeleton Research: A fundamental tool for disrupting actin filament networks to study cell structure, division, and intracellular transport.
• Cell Biology Studies: Used to investigate mechanisms of cell motility, adhesion, and morphological changes in response to stimuli.
• Pharmacological Screening: Serves as a reference compound in assays designed to discover novel actin-targeting agents or cytoprotective drugs.
• Toxicology Research: Employed as a model mycotoxin to study cellular responses to toxin exposure and mechanisms of cytotoxicity.
• Angiogenesis Inhibition Studies: Investigated for its potential to inhibit the formation of new blood vessels in cancer and other disease research.
• Membrane Trafficking Analysis: Used to examine the role of the actin cytoskeleton in endocytosis, exocytosis, and organelle movement.

Basic Information

Product Name	Cytochalasin E
CAS No.	36011-19-5
Molecular Formula	C28H35NO6
Molecular Weight	481.59 g/mol
Synonyms	Kodo-cytochalasin-1; NSC 238159; Phomin; Cytochalasin E (Phomin); [1S-(1α,7β,10β,11α,13α,16E,18E,20S*)]-20-(Acetyloxy)-11,18-dihydroxy-1,7-dimethyl-10-propyl-4-azaspiro[16.2.1]henicosa-16,18-diene-2,8,21-trione
EINECS	Contact for details

Quality Control

Our Cytochalasin E is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is subjected to comprehensive analytical testing, including HPLC for purity confirmation and structural verification. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, ethanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.