Description

Tocainide Hydrochloride is a Class 1b antiarrhythmic agent and a primary amine analog of lidocaine, designed for enhanced oral bioavailability. Its core value proposition lies in its sodium channel-blocking properties, which are critical for stabilizing cardiac membranes and managing ventricular arrhythmias. This high-purity active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers and research institutions developing and producing cardiac medications and conducting electrophysiological studies.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of oral antiarrhythmic drugs for the treatment of ventricular tachycardia and other serious cardiac rhythm disorders.
• Cardiac Research: A key reference standard and tool compound in preclinical and clinical research investigating sodium channel pharmacology and mechanisms of arrhythmia.
• Analytical Standard: Serves as a certified reference material (CRM) for quality control laboratories to ensure the identity, purity, and potency of drug products through HPLC, LC-MS, and spectroscopic methods.
• Metabolite Studies: Used in pharmacokinetic and metabolic pathway studies due to its well-characterized absorption and elimination profile.
• Formulation Development: Employed in the development of various solid oral dosage forms, such as tablets and capsules, requiring consistent particle size and purity.

Basic Information

Product Name	Tocainide Hydrochloride
CAS No.	35891-93-1
Molecular Formula	C11H16N2O • HCl
Molecular Weight	228.72 g/mol
Synonyms	2-Amino-2',6'-propionoxylidide hydrochloride; Tonocard (brand name); W-36095; 2-Amino-N-(2,6-dimethylphenyl)propanamide hydrochloride; 1-Methyl-2-(2,6-xylylcarbamoyl)ethylammonium chloride
EINECS	Contact for details

Quality Control

Our Tocainide Hydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets stringent specifications for pharmaceutical use. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material compliant with relevant pharmacopeial standards (e.g., USP, EP) upon request, ensuring traceability and regulatory support for your drug development and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.