Description

trans-Cyclobutane-1,2-Dicarboxamide is a high-purity, specialized organic compound featuring a rigid cyclobutane backbone with two amide groups in a trans configuration. This unique structure makes it a valuable chiral building block and intermediate for advanced pharmaceutical synthesis and fine chemical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in developing central nervous system (CNS) agents and enzyme inhibitors.
• Agrochemical Research: Serves as a precursor for creating new herbicides and pesticides with specific stereochemical activity.
• Ligand and Catalyst Development: Used in the design of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer Modification: Acts as a monomer or cross-linking agent to introduce rigidity and specific functionality into specialty polymers.
• Peptidomimetics: The constrained cyclobutane ring is employed to mimic peptide turn structures in medicinal chemistry.
• Academic & Industrial R&D: A versatile scaffold for exploring structure-activity relationships (SAR) and new chemical entities in discovery chemistry.

Basic Information

Product Name	trans-Cyclobutane-1,2-Dicarboxamide
CAS No.	35822-78-7
Molecular Formula	C6H10N2O2
Molecular Weight	142.16 g/mol
Synonyms	(1R,2R)-Cyclobutane-1,2-dicarboxamide; (1S,2S)-Cyclobutane-1,2-dicarboxamide; trans-1,2-Cyclobutanedicarboxamide; rel-(1R,2R)-1,2-Cyclobutanedicarboxamide; Cyclobutane-1,2-dicarboxamide, trans-; 1,2-Cyclobutanedicarboxylic acid diamide; (R,R)-1,2-Cyclobutanedicarboxamide; (S,S)-1,2-Cyclobutanedicarboxamide
EINECS	Contact for details

Quality Control

Our trans-Cyclobutane-1,2-Dicarboxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.