Description

7-(1,2-Dihydroxypropyl)-5,6,7,8-Tetrahydrobiopterin is a synthetic, reduced form of biopterin, a critical cofactor in enzymatic reactions. This compound matters for its essential role in supporting the function of aromatic amino acid hydroxylases, which are pivotal in neurotransmitter synthesis and metabolic pathways. It is primarily needed by pharmaceutical R&D teams, biochemical researchers, and manufacturers of high-purity reference standards and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Research & Development: As a key cofactor in studies of phenylalanine, tyrosine, and tryptophan hydroxylases for neurological and metabolic disorder research.
• Enzyme Activity Assays: Used in in vitro diagnostic kits and biochemical assays to measure the activity of enzymes dependent on tetrahydrobiopterin (BH4).
• Reference Standard: Serves as a high-purity analytical standard for quality control in the production of related pharmaceutical compounds and research chemicals.
• Cell Culture & Neuroscience Studies: Employed in cell-based models to investigate nitric oxide synthase function and neurotransmitter biosynthesis pathways.
• Precursor for Advanced Synthesis: Utilized as a building block in the synthetic preparation of more complex biopterin derivatives and labeled compounds.

Basic Information

Product Name	7-(1,2-Dihydroxypropyl)-5,6,7,8-Tetrahydrobiopterin
CAS No.	35818-62-3
Molecular Formula	C9H15N5O4
Molecular Weight	257.25 g/mol
Synonyms	6-(L-erythro-1,2-Dihydroxypropyl)-5,6,7,8-tetrahydropterin; (6R)-5,6,7,8-Tetrahydro-6-(1,2-dihydroxypropyl)-biopterin; 7,8-Dihydro-6-(1,2-dihydroxypropyl)pterin; BH4 derivative; Tetrahydrobiopterin analog; Reduced Biopterin cofactor; 6-(1,2-Dihydroxypropyl)-5,6,7,8-tetrahydropterin
EINECS	Contact for details

Quality Control

Our 7-(1,2-Dihydroxypropyl)-5,6,7,8-Tetrahydrobiopterin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. For long-term storage, desiccate at -20°C. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.