Description

Nalpha-Fmoc-L-Tryptophan CAS NO 35737-15-6 is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled and sequential assembly of complex peptides and proteins in research and pharmaceutical development. It is primarily required by biotechnology companies, academic research institutions, and pharmaceutical manufacturers engaged in peptide-based drug discovery, therapeutic agent development, and biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical Intermediates: For the research and production of peptide-based active pharmaceutical ingredients (APIs) and therapeutic candidates.
• Bioconjugation and Labeling: Used to incorporate the tryptophan moiety, a fluorescent amino acid, into peptides for spectroscopic studies and probe development.
• Combinatorial Chemistry Libraries: Serves as a building block for creating diverse peptide libraries for high-throughput screening in drug discovery.
• Biochemical Research: Employed in academic and industrial labs for studying protein structure, function, and protein-protein interactions.
• Antibody-Drug Conjugate (ADC) Development: Can be utilized in the synthesis of peptide linkers for targeted drug delivery systems.

Basic Information

Product Name	Nalpha-Fmoc-L-Tryptophan
CAS No.	35737-15-6
Molecular Formula	C26H22N2O4
Molecular Weight	426.47 g/mol
Synonyms	Fmoc-L-Tryptophan; Fmoc-Trp-OH; Fmoc-Tryptophan; N-(9-Fluorenylmethoxycarbonyl)-L-tryptophan; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid; 9-Fluorenylmethyloxycarbonyl-L-tryptophan; N-α-Fmoc-L-tryptophan; N-Fmoc-L-tryptophan
EINECS	Contact for details

Quality Control

Our Nalpha-Fmoc-L-Tryptophan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and consistency for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.