Description

Tetrahydrothiamine Pyrophosphate is a key phosphorylated derivative of thiamine (vitamin B1) and a crucial intermediate in enzymatic cofactor biosynthesis. This compound is essential for research and development in biochemistry and enzymology, particularly in the study of thiamine-dependent enzymes. It is primarily utilized by researchers and manufacturers in the pharmaceutical, nutraceutical, and life science sectors for advanced biochemical applications.

Application

• Biochemical Research: Critical substrate and reference standard for studying thiamine pyrophosphate (TPP)-dependent enzymes and metabolic pathways.
• Enzyme Mechanism Studies: Used to investigate the catalytic mechanisms of transketolase, pyruvate dehydrogenase, and other TPP-utilizing enzymes.
• Pharmaceutical Development: Serves as a key intermediate in the research and synthesis of novel therapeutic agents targeting metabolic disorders.
• Nutraceutical Research: Employed in advanced studies on vitamin B1 metabolism and the development of enhanced nutritional supplements.
• Diagnostic Reagent Manufacturing: Used in the formulation of specialized reagents for clinical diagnostics and metabolic assay kits.
• Academic & Industrial R&D: A fundamental tool for universities and contract research organizations (CROs) exploring cellular metabolism and cofactor biology.

Basic Information

Product Name	Tetrahydrothiamine Pyrophosphate
CAS No.	35728-83-7
Molecular Formula	C12H20N4O7P2S
Molecular Weight	426.32 g/mol
Synonyms	THTPP; Tetrahydrothiamine Diphosphate; Dihydrothiamine Pyrophosphate; Thiamine Tetrahydro Pyrophosphate; Tetrahydrothiamin Pyrophosphate; 2-[3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl tetrahydro triphosphate; Allithiamine Pyrophosphate Derivative
EINECS	Contact for details

Quality Control

Our Tetrahydrothiamine Pyrophosphate is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.