Description

D-Proline, 3-Amino-, (3R)-Rel- (9Ci) is a non-proteinogenic amino acid derivative featuring a stereochemically defined D-proline backbone with an amino substituent at the 3-position. This compound matters as a sophisticated chiral building block and intermediate, essential for the synthesis of complex bioactive molecules where precise stereochemistry is critical. It is primarily needed by research institutions and pharmaceutical companies engaged in advanced medicinal chemistry, peptide mimetic development, and the production of chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational constraints and modify the biological activity, stability, and bioavailability of peptide-based drug candidates.
• Asymmetric Catalysis: Serves as a precursor or ligand component in the design of chiral catalysts for enantioselective synthesis.
• Biochemical Research: Employed as a specialized substrate or inhibitor in enzymatic studies and metabolic pathway investigations.
• Agrochemical Synthesis: Utilized in the development of advanced, chiral agrochemicals with specific modes of action.
• Material Science: Potential building block for functionalized polymers and advanced materials requiring specific molecular recognition properties.

Basic Information

Product Name	D-Proline, 3-Amino-, (3R)-Rel- (9Ci)
CAS No.	35684-64-1
Molecular Formula	C5H10N2O2
Molecular Weight	130.15 g/mol
Synonyms	(3R)-3-Aminopiperidine-2-carboxylic Acid; (R)-3-Amino-D-proline; 3-Amino-D-proline; rel-(3R)-3-Aminopiperidine-2-carboxylic Acid; D-3-Aminoproline; (2R,3R)-3-Aminopiperidine-2-carboxylic Acid; 3-Amino-D-proline Hydrochloride (salt form); 35684-64-1
EINECS	Contact for details

Quality Control

Our D-Proline, 3-Amino-, (3R)-Rel- (9Ci) is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data, including HPLC purity, chiral purity, and residual solvent analysis, upon request. Our quality commitment supports cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.