Description

Methyl 4-(2,2,2-Trifluoroethoxy)Benzoate is a high-purity fluorinated aromatic ester, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the unique combination of the benzoate ester moiety and the trifluoroethoxy group, which imparts desirable properties like enhanced lipophilicity and metabolic stability to target molecules. This compound is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients, as well as by specialty chemical manufacturers for creating functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and plant growth regulators, where the fluorine atoms can improve bioactivity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, enhancing properties such as chemical resistance, thermal stability, and surface characteristics.
• Organic Synthesis Reagent: Acts as a protected or functionalized benzoic acid derivative in multi-step organic synthesis for academic and industrial research.
• Dye & Pigment Intermediate: Utilized in the production of specialized fluorinated dyes and pigments that require specific solubility and stability profiles.

Basic Information

Product Name	Methyl 4-(2,2,2-Trifluoroethoxy)Benzoate
CAS No.	35554-38-2
Molecular Formula	C10H9F3O3
Molecular Weight	234.17 g/mol
Synonyms	Methyl p-(2,2,2-Trifluoroethoxy)benzoate; Benzoic acid, 4-(2,2,2-trifluoroethoxy)-, methyl ester; 4-(2,2,2-Trifluoroethoxy)benzoic acid methyl ester; Methyl 4-(trifluoroethoxy)benzoate; Methyl 4-(β,β,β-trifluoroethoxy)benzoate; p-(Trifluoroethoxy)benzoic Acid Methyl Ester; Methyl para-(2,2,2-trifluoroethoxy)benzoate
EINECS	Contact for details

Quality Control

Our production of Methyl 4-(2,2,2-Trifluoroethoxy)Benzoate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to verify identity, potency, and impurity profiles. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP compliance for pharmaceutical applications and can accommodate specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.