Description

D-Proline, 1-(Aminoiminomethyl)- (9Ci) is a non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a valuable chiral building block and intermediate for the development of novel bioactive molecules and peptidomimetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, asymmetric synthesis, and the development of enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetic Research: Used to construct modified peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity of peptide-based drug candidates.
• Asymmetric Synthesis: Employed as a chiral auxiliary or catalyst component in stereoselective organic reactions to create enantiomerically pure compounds.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies to investigate biological pathways and mechanisms of action.
• Agrochemical Development: Potential intermediate for the synthesis of novel, chiral herbicides or plant growth regulators.
• Material Science: Investigated for incorporation into specialty polymers or functional materials requiring specific chiral centers.

Basic Information

Product Name	D-Proline, 1-(Aminoiminomethyl)- (9Ci)
CAS No.	35404-54-7
Molecular Formula	C6H11N3O2
Molecular Weight	157.17 g/mol
Synonyms	1-Amidinoproline; D-1-Amidinoproline; (R)-1-Amidinopyrrolidine-2-carboxylic acid; 1-Carbamimidoyl-D-proline; D-1-Carbamimidoylproline; Guanidino-D-proline; 35404-54-7; (2R)-1-Carbamimidoylpyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our D-Proline, 1-(Aminoiminomethyl)- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.