Description

(S)-tert-Butoxycarbonylamino-Cyclopentyl-Acetic Acid CAS NO 35264-06-3 is a high-purity chiral intermediate, specifically the Boc-protected (S)-enantiomer of 2-amino-2-cyclopentylacetic acid. This compound is critical for ensuring the stereochemical integrity and efficacy of advanced pharmaceutical compounds. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of protease inhibitors, antiviral drugs, and other small molecule therapeutics requiring a stereochemically defined cyclopentylglycine moiety.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a protected (S)-2-amino-2-cyclopentylacetic acid residue into peptide chains.
• API Development: Serves as a critical starting material or intermediate in the research and development (R&D) and scale-up production of new chemical entities (NCEs).
• Asymmetric Synthesis: Employed in chiral pool synthesis and as a precursor for catalysts or ligands used in asymmetric transformations.
• Bioconjugation: The carboxylic acid and protected amine functionalities allow for selective conjugation to biomolecules or other chemical entities.
• Chemical Biology Research: Used as a tool compound or labeled precursor in metabolic studies and proteomics research.

Basic Information

Product Name	(S)-tert-Butoxycarbonylamino-Cyclopentyl-Acetic Acid
CAS No.	35264-06-3
Molecular Formula	C₁₂H₂₁NO₄
Molecular Weight	243.30 g/mol
Synonyms	(S)-2-[(tert-Butoxycarbonyl)amino]-2-cyclopentylacetic acid; (S)-Boc-2-amino-2-cyclopentylacetic acid; (S)-N-Boc-2-amino-2-cyclopentylacetic acid; (S)-Boc-Cpg-OH; (S)-Boc-Cyclopentylglycine; (S)-2-(Boc-amino)-2-cyclopentylacetic acid; (S)-N-(tert-Butoxycarbonyl)-2-amino-2-cyclopentylacetic acid; (S)-α-[(tert-Butoxycarbonyl)amino]cyclopentaneacetic acid
EINECS	Contact for details

Quality Control

Our (S)-tert-Butoxycarbonylamino-Cyclopentyl-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.