Description

4,5-Dimethoxy-1-Cyanobenzocyclobutane is a high-value, multifunctional chemical intermediate characterized by its strained benzocyclobutane core and strategically placed cyano and methoxy substituents. This unique molecular architecture makes it a critical building block for the synthesis of complex organic frameworks, particularly in advanced pharmaceutical and materials science research. It is essential for R&D chemists and process development scientists working in medicinal chemistry, agrochemicals, and the development of specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets, leveraging the strained ring for unique structural motifs.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, where the benzocyclobutane unit can impart specific biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a core building block for advanced electronic materials, contributing to the molecular rigidity and electronic properties required for display and lighting technologies.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance thermal stability, chemical resistance, or to introduce cross-linking sites via the reactive cyano group.
• Organic Synthesis & Methodology: A valuable substrate in academic and industrial research for studying ring-opening reactions, cycloadditions, and other transformations of strained aromatic systems.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized chromophores and pigments for high-performance coatings and imaging applications.

Basic Information

Product Name	4,5-Dimethoxy-1-Cyanobenzocyclobutane
CAS No.	35202-54-1
Molecular Formula	C11H11NO2
Molecular Weight	189.21 g/mol
Synonyms	1-Cyano-4,5-dimethoxybenzocyclobutane; 4,5-Dimethoxybenzocyclobutane-1-carbonitrile; BCB-CN (Dimethoxy); 1,2-Dihydro-4,5-dimethoxy-1-cyanocyclobutabenzene; 4,5-Dimethoxy-1-cyanobicyclo[4.2.0]octa-1,3,5-triene
EINECS	Contact for details

Quality Control

Every batch of 4,5-Dimethoxy-1-Cyanobenzocyclobutane is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be sensitive to prolonged exposure to moisture and strong oxidizing agents. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.