Description

3-Trifluoromethyl-4,5,6,7-Tetrahydro-1H-Indazole is a high-purity, heterocyclic organic compound featuring a fused indazole core with a strategically positioned trifluoromethyl group. This structure makes it a valuable and versatile pharmaceutical intermediate and building block for medicinal chemistry research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Medicinal Chemistry Building Block: Used in hit-to-lead and lead optimization campaigns to introduce the metabolically stable trifluoromethyl group and the indazole pharmacophore, which can modulate potency, selectivity, and pharmacokinetic properties.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides, where the indazole scaffold can contribute to biological activity.
• Material Science: Investigated as a monomer or additive for creating specialty polymers and advanced organic materials with unique electronic or thermal properties.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	3-Trifluoromethyl-4,5,6,7-Tetrahydro-1H-Indazole
CAS No.	35179-55-6
Molecular Formula	C8H9F3N2
Molecular Weight	190.17 g/mol
Synonyms	4,5,6,7-Tetrahydro-3-(trifluoromethyl)-1H-indazole; 3-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole; 1H-Indazole, 4,5,6,7-tetrahydro-3-(trifluoromethyl)-; 3-Trifluoromethyl-4,5,6,7-tetrahydroindazole; 3-Trifluoromethyl-4,5,6,7-tetrahydro-2H-indazole; TFTHI; 35179-55-6 (CAS)
EINECS	Contact for details

Quality Control

Our 3-Trifluoromethyl-4,5,6,7-Tetrahydro-1H-Indazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical purity and consistency, meeting the stringent requirements for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.