Description

2'-Deoxy-n-(Trifluoroacetyl)Adenosine 3',5'-Bis(Trifluoroacetate) is a key trifluoroacetylated nucleoside derivative, primarily used as a critical synthetic intermediate in advanced organic and medicinal chemistry. This compound is essential for researchers and manufacturers requiring high-purity building blocks for oligonucleotide synthesis and the development of novel pharmaceutical agents, including antiviral and anticancer drugs. Its primary value lies in enabling precise chemical modifications to the adenosine scaffold, making it indispensable for biotechnology, pharmaceutical R&D, and fine chemical synthesis sectors globally.

Application

• Oligonucleotide Synthesis: Serves as a protected intermediate in the solid-phase synthesis of DNA and RNA analogs for research and therapeutic applications.
• Pharmaceutical Intermediate: A crucial building block in the development of nucleoside-based antiviral and anticancer prodrugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to modify the pharmacokinetic properties of nucleoside analogs.
• Bioconjugation & Labeling: Acts as a precursor for creating labeled nucleosides used in diagnostic assays and imaging probes.
• Fine Chemical Synthesis: Employed in custom synthesis and the production of specialized nucleoside derivatives for advanced material science.
• Academic & Institutional Research: Utilized in biochemical and molecular biology laboratories for studying enzyme mechanisms and nucleic acid interactions.

Basic Information

Product Name	2'-Deoxy-n-(Trifluoroacetyl)Adenosine 3',5'-Bis(Trifluoroacetate)
CAS No.	35170-10-6
Molecular Formula	C15H12F9N5O7
Molecular Weight	545.27 g/mol
Synonyms	2'-Deoxy-N6-(trifluoroacetyl)adenosine 3',5'-bis(trifluoroacetate); 2'-Deoxyadenosine, N6-(trifluoroacetyl)-, 3',5'-bis(trifluoroacetate); N6-Trifluoroacetyl-2'-deoxyadenosine 3',5'-bis(trifluoroacetate); 2'-Deoxy-N-(trifluoroacetyl)adenosine 3',5'-bis(trifluoroacetate); TFA-dA; Protected 2'-Deoxyadenosine Derivative; N6-TFA-2'-dA 3',5'-di-TFA ester
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-n-(Trifluoroacetyl)Adenosine 3',5'-Bis(Trifluoroacetate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.