Description

18-Hydroxy-11-Deoxycortisol is a significant steroid intermediate and reference standard with the CAS registry number 35121-42-7. This compound is crucial for research and development in the synthesis of more complex corticosteroids and for analytical method development. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of fine chemicals and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of more potent corticosteroid drugs and other steroid-based therapeutics.
• Reference Standard: Used for the calibration of analytical instruments (HPLC, GC-MS) and for method validation in quality control laboratories to ensure accurate quantification.
• Biochemical Research: Employed in metabolic pathway studies, enzyme inhibition assays, and research related to steroid hormone biosynthesis and regulation.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor or a critical intermediate in the development and scale-up of new steroid-based APIs.
• Academic & Clinical Studies: Utilized in universities and hospitals for investigating adrenal function and related endocrine disorders.

Basic Information

Product Name	18-Hydroxy-11-Deoxycortisol
CAS No.	35121-42-7
Molecular Formula	C21H30O5
Molecular Weight	362.46 g/mol
Synonyms	18-Hydroxycortexolone; 18-Hydroxy-Reichstein's Substance S; 11-Deoxy-18-hydroxycortisol; 18,21-Dihydroxypregn-4-ene-3,20-dione; 18-Hydroxy-11-deoxycorticosterone; 18-OH-DOC; Reichstein's Substance R
EINECS	Contact for details

Quality Control

Our 18-Hydroxy-11-Deoxycortisol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.