Description

3-Fluoromalic Acid is a fluorinated derivative of malic acid, serving as a versatile chiral building block and intermediate in advanced organic synthesis. Its unique structure, featuring both carboxylic acid and fluorine functional groups, makes it valuable for introducing fluorinated motifs into target molecules, which can significantly alter their physicochemical and biological properties. This compound is particularly relevant for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of fluorinated active pharmaceutical ingredients (APIs), including potential protease inhibitors and other bioactive molecules.
• Agrochemical Synthesis: Used in the creation of novel fluorinated herbicides, pesticides, and plant growth regulators, where the fluorine atom can enhance stability and bioavailability.
• Biochemical Research: Acts as a substrate or inhibitor analog in enzymatic studies, particularly those involving malic acid metabolism or fluorinated compound interactions.
• Ligand and Catalyst Development: Employed in the synthesis of complex fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Precursor: Serves as a monomer or functionalization agent for creating specialty polymers and coatings with tailored surface properties.
• Fluorine Chemistry Research: A fundamental compound for academic and industrial research exploring new methods for C-F bond formation and the synthesis of complex fluoroorganics.

Basic Information

Product Name	3-Fluoromalic Acid
CAS No.	34917-27-6
Molecular Formula	C4H5FO5
Molecular Weight	152.08 g/mol
Synonyms	3-Fluoromalic Acid; (2R,3S)-3-Fluoromalic Acid; 3-Fluorohydroxysuccinic Acid; 3-Fluoro-2-hydroxybutanedioic Acid; 2-Hydroxy-3-fluorobutanedioic Acid; Fluoromalic Acid; 3-Fluoro-DL-malic Acid
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoromalic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC), chiral purity, and impurity profiles. Our quality protocols are designed to support applications in GMP and cGMP environments where traceability and consistency are paramount.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomeric excess)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.