Description

1-(Difluoromethoxy)-4-Fluorobenzene is a specialized fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its unique difluoromethoxy and fluoro substituents make it a valuable precursor for introducing specific fluorine-containing motifs into target molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, where its structural features can enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the difluoromethoxy pharmacophore.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where fluorination can improve lipophilicity and environmental stability.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in display technologies.
• Organic Electronics: Potential precursor in the synthesis of fluorinated organic semiconductors and dielectric materials.
• Advanced Polymer Modification: Employed to incorporate fluorine atoms into polymer backbones to alter thermal, chemical, and surface properties.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for exploring new fluorination methodologies and creating complex molecular architectures.

Basic Information

Product Name	1-(Difluoromethoxy)-4-Fluorobenzene
CAS No.	34888-09-0
Molecular Formula	C7H5F3O
Molecular Weight	162.11 g/mol
Synonyms	4-Fluoro-1-(difluoromethoxy)benzene; p-Fluorophenyl difluoromethyl ether; Difluoromethoxy-4-fluorobenzene; 4-Fluorophenyl difluoromethyl ether; 1-Fluoro-4-(difluoromethoxy)benzene; (4-Fluorophenyl)difluoromethyl ether; Benzene, 1-(difluoromethoxy)-4-fluoro-
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethoxy)-4-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Recommended storage temperature is between 2°C and 8°C for long-term stability. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual ≤ 1.0%, Total ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.