Description

3-(Difluoromethoxy)Fluorobenzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique difluoromethoxy substituent adjacent to a fluorine atom makes it a valuable precursor for introducing specific fluorine patterns into target molecules, which is critical for modulating the physicochemical and biological properties of final compounds. This high-purity intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates requiring specific fluorination patterns to enhance metabolic stability, bioavailability, or receptor binding affinity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the introduction of fluorine atoms can improve efficacy, environmental stability, and selectivity.
• Liquid Crystal & Electronic Materials: Serves as a building block for fluorinated components in liquid crystal displays (LCDs) and dielectric materials, where fluorine content influences dielectric constant and thermal stability.
• Organic Synthesis & Catalysis Research: Employed in academic and industrial R&D for exploring new fluorination methodologies, cross-coupling reactions, and as a ligand precursor in catalyst design.
• Advanced Polymer Modification: Used to incorporate fluorine-containing aromatic units into polymer backbones, enhancing material properties such as chemical resistance, thermal stability, and optical clarity for high-performance plastics and coatings.

Basic Information

Product Name	3-(Difluoromethoxy)Fluorobenzene
CAS No.	34888-08-9
Molecular Formula	C7H5F3O
Molecular Weight	162.11 g/mol
Synonyms	1-Fluoro-3-(difluoromethoxy)benzene; m-(Difluoromethoxy)fluorobenzene; 3-Fluorophenyl difluoromethyl ether; Benzene, 1-fluoro-3-(difluoromethoxy)-; Fluorobenzene, 3-(difluoromethoxy)-; Difluoromethoxy-3-fluorobenzene
EINECS	Contact for details

Quality Control

Every batch of 3-(Difluoromethoxy)Fluorobenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and reactive metals. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize moisture uptake and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.