Description

(7R)-3-Methyl-8-Oxo-7-(2-(Thiophen-2-Yl)Acetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a high-purity advanced pharmaceutical intermediate, specifically a cephalosporin nucleus derivative. This compound is critical for the synthesis of next-generation β-lactam antibiotics, offering a key chiral building block for complex molecular architectures. It is primarily required by pharmaceutical R&D laboratories and API manufacturers focused on developing novel antibacterial agents with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: Core building block for the synthesis of advanced cephalosporin-class antibiotics.
• Antibacterial Drug Development: Used in research and production of novel β-lactam antibiotics targeting resistant bacterial strains.
• Active Pharmaceutical Ingredient (API) Synthesis: A key chiral precursor in multi-step synthetic routes for final API manufacturing.
• Biochemical Research: Serves as a standard or reagent in studies exploring β-lactamase inhibition and antibiotic mechanisms of action.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic pathways from laboratory to pilot and commercial production scales.

Basic Information

Product Name	(7R)-3-Methyl-8-Oxo-7-(2-(Thiophen-2-Yl)Acetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	34691-02-6
Molecular Formula	C15H14N2O4S2
Molecular Weight	350.41 g/mol
Synonyms	7-ACA Thiophene Derivative; 7β-[(2-Thienylacetyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; 7-ADCA Thiophene-2-Acetamide Derivative; (6R,7R)-7-[(2-Thiopheneacetyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Cephalosporanic Acid Derivative; 7-TACA; 7β-(2-Thienylacetamido)-3-methylcephem-4-carboxylic Acid
EINECS	Contact for details

Quality Control

Our (7R)-3-Methyl-8-Oxo-7-(2-(Thiophen-2-Yl)Acetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with stringent specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (7R isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.