Description

Pentamethylphenylacetonitrile is a high-purity, multi-substituted aromatic nitrile building block of significant interest in advanced organic synthesis. Its unique sterically hindered structure, featuring a fully methylated phenyl ring, makes it a critical precursor for the development of complex molecules, particularly in pharmaceutical and material science research. This compound is essential for chemists and R&D teams in the fine chemical, agrochemical, and advanced material sectors seeking to introduce bulky, lipophilic motifs into their target architectures.

Application

• Pharmaceutical Intermediate: Serves as a key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially those requiring sterically hindered, lipophilic aromatic systems.
• Ligand and Catalyst Development: Used in the preparation of specialized phosphine ligands and organometallic catalysts for asymmetric synthesis and cross-coupling reactions.
• Agrochemical Research: Acts as a building block for creating new generation herbicides and fungicides with enhanced stability and activity.
• Advanced Material Precursor: Employed in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its rigid, multi-methylated structure.
• Dye and Pigment Chemistry: Utilized as an intermediate for developing specialized dyes and pigments with unique color fastness and solubility properties.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry, particularly in nitrile chemistry and C-H functionalization.

Basic Information

Product Name	Pentamethylphenylacetonitrile
CAS No.	34688-70-5
Molecular Formula	C₁₄H₁₇N
Molecular Weight	199.29 g/mol
Synonyms	2-(2,3,4,5,6-Pentamethylphenyl)acetonitrile; Pentamethylbenzyl Cyanide; (Pentamethylphenyl)acetonitrile; α-Cyano-2,3,4,5,6-pentamethyltoluene; Pentamethylbenzeneacetonitrile; NSC 403120; Pentamethylphenylacetonitrile; 34688-70-5
EINECS	Contact for details

Quality Control

Our Pentamethylphenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.