Description

Cefamandole CAS NO 34444-01-4 is a second-generation cephalosporin antibiotic belonging to the cephamycin class. It is valued for its broad-spectrum activity against a wide range of Gram-positive and Gram-negative bacteria, including β-lactamase-producing strains. This makes it a critical intermediate and active pharmaceutical ingredient (API) for manufacturers in the pharmaceutical industry, particularly for producing sterile injectable formulations.

Application

• Pharmaceutical API: Primary use as the active pharmaceutical ingredient in the synthesis of sterile injectable antibiotic formulations.
• Antibiotic Production: A key intermediate in the manufacturing process of cefamandole sodium, the sodium salt form used in medicinal products.
• Research & Development: Used in microbiological and pharmacological research to study antibiotic efficacy and resistance mechanisms.
• Veterinary Medicine: Potential application in developing antibacterial treatments for veterinary use.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control laboratories in pharmaceutical analysis.

Basic Information

Product Name	Cefamandole
CAS No.	34444-01-4
Molecular Formula	C18H18N6O5S2
Molecular Weight	462.50 g/mol
Synonyms	Cefamandole; Cefamandolum; Cefamandole Free Acid; (6R,7R)-7-[[(2R)-2-Hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Mandol; Kefandol; Cefamandole Nafate (precursor); Cefamandole Acid
EINECS	Contact for details

Quality Control

Our Cefamandole is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.