Description

Boc-L-Dab(Boc) CAS NO 34404-27-8 is a protected derivative of the non-proteinogenic amino acid L-2,4-diaminobutyric acid (L-Dab), featuring two tert-butoxycarbonyl (Boc) protecting groups. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering orthogonal protection strategies for side-chain and backbone amines. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents, including antimicrobial peptides and enzyme inhibitors.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for incorporating the L-Dab residue into peptide chains with protected side-chain functionality.
• Antimicrobial Peptide (AMP) Research: For the development of novel AMPs where the diaminobutyric acid moiety can influence charge, helicity, and membrane interaction.
• Pharmaceutical Intermediate: In the synthesis of active pharmaceutical ingredients (APIs) and prodrugs that require a selectively protected diamine structure.
• Bioconjugation and Linker Chemistry: Serving as a versatile scaffold for creating cleavable linkers in antibody-drug conjugates (ADCs) or other bioconjugates.
• Chemical Biology Probes: For constructing labeled peptides and tools used to study enzyme mechanisms and protein-protein interactions.
• Custom Peptide Service: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing services.

Basic Information

Product Name	Boc-L-Dab(Boc)
CAS No.	34404-27-8
Molecular Formula	C₁₄H₂₆N₂O₆
Molecular Weight	318.37 g/mol
Synonyms	Nα,Nγ-Bis(tert-butoxycarbonyl)-L-2,4-diaminobutyric acid; (S)-2,4-Bis((tert-butoxycarbonyl)amino)butanoic acid; Boc-L-Dab(Boc)-OH; Nα-Boc-Nγ-Boc-L-2,4-diaminobutyric acid; L-2,4-Diaminobutyric acid bis-Boc derivative; Boc-Dab(Boc)-OH; (S)-2,4-Bis(Boc-amino)butyric acid; BOC-DAB(BOC)-OH
EINECS	Contact for details

Quality Control

Our Boc-L-Dab(Boc) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.