Description

Mal-Peg2-Alcohol CAS NO 34321-81-8 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group at one terminus and a hydroxyl group at the other. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the site-specific coupling of biomolecules such as peptides, proteins, and antibodies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for creating stable, functionalized conjugates with improved solubility and pharmacokinetic properties.

Application

• Bioconjugation Linker: For the site-specific attachment of thiol-containing biomolecules (e.g., cysteine residues in proteins/peptides) to hydroxyl-functionalized surfaces, particles, or other molecules.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key intermediate in constructing linker-payload systems for targeted cancer therapies.
• PEGylation Reagent: Used to modify therapeutic proteins and peptides to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Surface Functionalization: For modifying nanoparticles, quantum dots, or biosensor surfaces to introduce reactive maleimide groups for subsequent biomolecule immobilization.
• Cross-linking Agent: In the preparation of hydrogels, polymer networks, or biomaterial scaffolds requiring specific, covalent cross-links.
• Diagnostic Probe Synthesis: Facilitates the labeling of antibodies, enzymes, or other detection molecules with fluorescent dyes or other reporter groups via the hydroxyl terminus.

Basic Information

Product Name	Mal-Peg2-Alcohol
CAS No.	34321-81-8
Molecular Formula	C11H17NO5
Molecular Weight	243.26 g/mol
Synonyms	3-Maleimidopropionic acid 2-(2-hydroxyethoxy)ethyl ester; Maleimide-PEG2-alcohol; 2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethanol; 1-(2-(2-Hydroxyethoxy)ethyl)-1H-pyrrole-2,5-dione; Mal-PEG2-OH; mPEG2-maleimide; PEG2 maleimide alcohol; Heterobifunctional PEG, Maleimide-PEG2-OH
EINECS	Contact for details

Quality Control

Our Mal-Peg2-Alcohol is manufactured under GMP-like conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, suitable for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent in-house specifications to meet the demands of critical bioconjugation workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Maleimide Content	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.