Description

Clioquinol Glucuronide is a key metabolite of the antimicrobial and antifungal agent clioquinol. This compound is of significant importance in pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and toxicology. It is primarily needed by analytical laboratories, pharmaceutical companies, and research institutions engaged in bioanalytical method development, metabolite identification, and regulatory safety assessments.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of clioquinol and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, bioavailability, and excretion profiles of clioquinol in preclinical and clinical research.
• Bioanalytical Method Development: Serves as a critical standard for developing and validating sensitive HPLC, LC-MS, or GC-MS methods for metabolite profiling.
• Toxicology and Safety Assessment: Employed in studies to understand the safety, toxicity, and potential side effects associated with clioquinol administration.
• Impurity Profiling: Used to identify and quantify glucuronide conjugate impurities in clioquinol active pharmaceutical ingredient (API) batches.
• Academic and Institutional Research: Applied in biochemical and pharmacological research to study the conjugation mechanisms and activity of drug metabolites.

Basic Information

Item	Detail
Product Name	Clioquinol Glucuronide
CAS No.	34296-97-4
Molecular Formula	C18H19Cl2NO8
Molecular Weight	448.25 g/mol
Synonyms	5-Chloro-7-iodo-8-quinolinyl β-D-glucopyranosiduronic acid; Clioquinol β-D-Glucuronide; Iodochlorhydroxyquin glucuronide; 5-Chloro-7-iodoquinolin-8-yl β-D-glucopyranosiduronic acid; Chinoform glucuronide; Clioquinol Glucuronide Conjugate; Vioform® glucuronide metabolite
EINECS	Contact for details

Quality Control

Our Clioquinol Glucuronide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and determination of residual solvents and moisture content. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to ensure traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.