Description

Granisetron-D3 is a deuterated isotopologue of the potent and selective 5-HT₃ receptor antagonist Granisetron, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in advanced LC-MS/MS analysis.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of Granisetron in complex biological matrices such as plasma, serum, and urine, improving method robustness and data integrity.
• Pharmacokinetic (PK) and Bioequivalence Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and pre-clinical research.
• Drug Metabolism Research: Used in metabolite identification and profiling studies to understand the biotransformation pathways of Granisetron.
• Quality Control in Pharmaceutical Manufacturing: Supports analytical method development and validation for the quality assurance of Granisetron-based drug products.
• Forensic and Toxicology Analysis: Aids in the accurate detection and measurement of Granisetron in forensic investigations.

Basic Information

Product Name	Granisetron-D3
CAS No.	34252-44-3
Molecular Formula	C18H21D3N4O
Molecular Weight	315.42 g/mol
Synonyms	1-Methyl-N-((1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide-d3; Granisetron-d3; BRL 43694-d3; Kytril-d3; Sancuso-d3; Deuterated Granisetron; Granisetron Internal Standard
EINECS	Contact for details

Quality Control

Our Granisetron-D3 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by comprehensive analytical documentation, including detailed Certificates of Analysis (COA) that report isotopic enrichment (typically >98% D), chemical purity (by HPLC), and confirm structural identity. We support compliance with cGMP and ICH guidelines for analytical standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.