Description

n-(p-Tosyl)-L-Isoleucine is a protected amino acid derivative, specifically the tosyl (p-toluenesulfonyl) derivative of L-Isoleucine. This compound is a crucial chiral building block in the synthesis of complex peptides and pharmaceutical intermediates, offering a protected amine group for selective chemical transformations. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing new therapeutic agents and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Serves as a protected amino acid residue in solid-phase and solution-phase peptide synthesis (SPPS).
• Bioconjugation: Used in the development of antibody-drug conjugates (ADCs) and other targeted biopharmaceuticals.
• Chemical Biology Research: Employed as a tool compound for studying enzyme mechanisms and protein-protein interactions.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in the synthesis of non-proteinogenic amino acids and other enantiomerically pure compounds.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, catalysts, and ligands for asymmetric catalysis.

Basic Information

Product Name	n-(p-Tosyl)-L-Isoleucine
CAS No.	34235-81-9
Molecular Formula	C16H25NO4S
Molecular Weight	327.44 g/mol
Synonyms	N-[(4-Methylphenyl)sulfonyl]-L-isoleucine; L-Isoleucine, N-[(4-methylphenyl)sulfonyl]-; N-Tosyl-L-isoleucine; p-Toluenesulfonyl-L-isoleucine; (2S,3S)-2-[(4-Methylphenyl)sulfonamido]-3-methylpentanoic acid; Tosyl-Ile-OH; N-p-Tosyl-L-isoleucine
EINECS	Contact for details

Quality Control

Our n-(p-Tosyl)-L-Isoleucine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity standards suitable for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.