Description

9Alpha-11Alpha, 15S-Trihydroxy-Prosta-5Z, 13E-Dien-1-Oic-3,3,4,4-D4 Acid is a high-purity, deuterium-labeled analog of a key prostaglandin metabolite, specifically designed for advanced research and analytical applications. This compound is essential for use as an internal standard in mass spectrometry, enabling precise quantification and metabolic profiling studies. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and academic institutions focused on lipidomics, eicosanoid pathway analysis, and drug metabolism and pharmacokinetics (DMPK) studies.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of prostaglandins and related eicosanoids in complex biological matrices like plasma, serum, and tissue homogenates.
• Metabolite Profiling & Biomarker Discovery: Used in lipidomics research to study inflammation, pain pathways, and cardiovascular diseases by tracing metabolic pathways.
• Drug Development & DMPK Studies: Employed in pharmaceutical R&D to investigate the metabolism, bioavailability, and clearance of drug candidates affecting the arachidonic acid cascade.
• Clinical Research: Supports studies aiming to correlate eicosanoid levels with disease states, treatment efficacy, and patient outcomes.
• Stable Isotope Labeling Experiments (SILE): Facilitates advanced mechanistic studies in biochemistry and molecular biology due to its deuterium labels.
• Reference Material for Analytical Method Development: Serves as a certified reference material for validating and calibrating analytical methods in regulated environments.

Basic Information

Product Name	9Alpha-11Alpha, 15S-Trihydroxy-Prosta-5Z, 13E-Dien-1-Oic-3,3,4,4-D4 Acid
CAS No.	34210-11-2
Molecular Formula	C20H28D4O6
Molecular Weight	368.48 g/mol (approx.)
Synonyms	9α,11α,15S-Trihydroxy-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 Acid; Deuterated PGD2 Metabolite; 9,11,15-Trihydroxyprosta-5,13-dien-1-oic-3,3,4,4-d4 Acid; d4-9,11,15-Trihydroxyprosta-5,13-dien-1-oic Acid; 9,11,15-Trihydroxyprostadienoic Acid-d4; PGD2 Metabolite-d4; Tetradeuterated 9,11,15-Trihydroxyprosta-5,13-dien-1-oic Acid
EINECS	Contact for details

Quality Control

Our deuterated standards are manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and high-resolution mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment, chemical purity, and chromatographic data. We support compliance with GMP/GLP guidelines for research and regulatory submission purposes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to reach room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (d4)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.