Description

Propafenone Hydrochloride is a high-purity pharmaceutical active ingredient (API) belonging to the class IC antiarrhythmic agents. It is critical for the formulation of medications used to treat and manage serious cardiac arrhythmias, such as ventricular tachycardia and atrial fibrillation. This compound is essential for pharmaceutical manufacturers and research institutions developing cardiovascular therapies. We supply Propafenone Hydrochloride CAS NO 34183-22-7 in grades suitable for GMP manufacturing and advanced R&D applications.

Application

• Pharmaceutical API: Primary active ingredient in antiarrhythmic drug formulations.
• Cardiovascular Research: Key reference standard and biochemical tool for studying cardiac ion channel (sodium channel) blockade.
• Generic Drug Manufacturing: Sourcing for the production of generic versions of branded antiarrhythmic medications.
• Analytical Standard: Used as a high-purity standard in HPLC, LC-MS, and other analytical methods for quality control and pharmacokinetic studies.
• Preclinical & Clinical Development: Serves as the core component in new drug development for heart rhythm disorders.

Basic Information

Product Name	Propafenone Hydrochloride
CAS No.	34183-22-7
Molecular Formula	C21H27NO3 • HCl
Molecular Weight	377.91 g/mol
Synonyms	1-[2-[2-Hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone Hydrochloride; Propafenone HCl; 2'-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone Hydrochloride; Rytmonorm (trade name); Rythmol (trade name); Fenopraine; SA-79; Baxarytmon
EINECS	Contact for details

Quality Control

Our Propafenone Hydrochloride is manufactured and tested under strict quality management systems. We offer material compliant with major pharmacopoeial standards, including USP and EP monographs. Every batch undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) detailing all test results is provided to ensure full traceability and compliance for your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.5% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.