Description

Haloperidol Metabolite Ii is a key reference standard and analytical intermediate, specifically the reduced ketone metabolite of the antipsychotic drug haloperidol. This compound is essential for pharmaceutical research and development, enabling precise metabolic profiling, pharmacokinetic studies, and the validation of bioanalytical methods. It is primarily utilized by research institutions, pharmaceutical manufacturers, and contract testing laboratories focused on neuropharmacology and drug safety assessment.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantitative and qualitative analysis of haloperidol and its metabolites in biological matrices.
• Metabolite Identification & Profiling: Critical for in vitro and in vivo studies to understand the metabolic pathways and biotransformation of haloperidol.
• Bioanalytical Method Development & Validation: Used to calibrate equipment and validate HPLC, LC-MS/MS, and GC-MS methods for accurate detection and quantification.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Research: Enables the study of drug absorption, distribution, metabolism, and excretion (ADME) for haloperidol.
• Impurity Characterization: Acts as a known impurity or degradation product standard for haloperidol drug substance and product quality control.
• Toxicological Studies: Supports investigations into the safety profile and potential toxicity of haloperidol metabolites.

Basic Information

Item	Detail
Product Name	Haloperidol Metabolite Ii
CAS No.	34104-67-1
Molecular Formula	C21H23ClFNO2
Molecular Weight	375.87 g/mol
Synonyms	4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinol; Reduced Haloperidol; Haloperidol Metabolite II; Haloperidol, Reduced; 1-(4-Fluorobenzoyl)-4-(4-chlorophenyl)-4-hydroxypiperidine; 4-Fluoro-4'-(4-hydroxy-4-(p-chlorophenyl)piperidino)butyrophenone; γ-(4-Fluorobenzoyl)propyl-4-hydroxy-4-(p-chlorophenyl)piperidine
EINECS	Contact for details

Quality Control

Our Haloperidol Metabolite Ii is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of related substances. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to ensure traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.