Description

Probenecid Acyl -D-Glucuronide is a key metabolite of the uricosuric drug probenecid, formed via glucuronidation in the liver. This compound is of critical importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is an essential reference standard for laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors requiring high-purity materials for accurate analytical work.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of probenecid and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Critical for investigating the metabolic pathways, clearance mechanisms, and half-life of probenecid.
• Bioanalytical Method Development: Used to validate HPLC, LC-MS, and LC-MS/MS methods for clinical and preclinical studies.
• Toxicology and Safety Assessment: Serves as a biomarker in studies assessing drug safety and potential metabolite-related toxicity.
• Academic and Institutional Research: Employed in universities and research institutes for fundamental studies on glucuronidation enzymes (UGTs).
• Quality Control in Manufacturing: Used to ensure the consistency and purity of probenecid active pharmaceutical ingredient (API) and related formulations.

Basic Information

Item	Details
Product Name	Probenecid Acyl -D-Glucuronide
CAS No.	34017-15-7
Molecular Formula	C21H27NO10S
Molecular Weight	485.51 g/mol
Synonyms	Probenecid Acyl Glucuronide; Probenecid 1-O-Acyl-β-D-Glucuronide; Probenecid Glucuronide; 4-[(Dipropylamino)sulfonyl]benzoic acid 1-(β-D-glucopyranuronosyl) ester; p-(Dipropylsulfamoyl)benzoic acid glucuronide; Benzoic acid, 4-[(dipropylamino)sulfonyl]-, 1-(β-D-glucopyranuronosyl) ester; Probenecid metabolite M1
EINECS	Contact for details

Quality Control

Our Probenecid Acyl -D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.