Description

Propylthiouracil n-B-D-Glucuronide is a key glucuronidated metabolite of the antithyroid drug propylthiouracil. This compound is of significant value in pharmaceutical research and development, particularly for metabolic and pharmacokinetic studies. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in drug metabolism, toxicology, and analytical method development.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of propylthiouracil and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Critical for studying the Phase II conjugation pathways, metabolic stability, and clearance mechanisms of propylthiouracil.
• Analytical Method Development: Serves as a critical standard for developing and validating HPLC, LC-MS, and LC-MS/MS methods in bioanalytical laboratories.
• Toxicology Studies: Employed in investigations to understand the metabolic fate and potential toxicological profiles associated with propylthiouracil therapy.
• Clinical Research: Used in studies monitoring patient drug metabolism and adherence, especially in treatments for hyperthyroidism (Graves' disease).
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., with FDA, EMA) requiring detailed metabolite identification and characterization.

Basic Information

Product Name	Propylthiouracil n-B-D-Glucuronide
CAS No.	33987-24-5
Molecular Formula	C16H22N2O7S
Molecular Weight	386.42 g/mol
Synonyms	6-Propyl-2-sulfanylidene-1H-pyrimidin-4-yl β-D-glucopyranosiduronic acid; Propylthiouracil Glucuronide; PTU-Glucuronide; 6-Propyl-2-thiouracil Glucuronide; 6-n-Propyl-2-thiouracil Glucuronide; 4-Hydroxy-6-propyl-2-mercaptopyrimidine β-D-Glucuronide; 6-Propyl-2-mercapto-4-pyrimidinol β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Propylthiouracil n-B-D-Glucuronide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry standards for reference materials, and custom purity grades are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.