Description

3-Chloro-2-Hydroxypropiononitrile is a versatile bifunctional organic intermediate containing both a reactive nitrile and a chlorohydrin group. This compound matters for its role as a key building block in the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research and development. Industries that need it include fine chemical manufacturers, pharmaceutical R&D labs, and agrochemical producers seeking to create novel active ingredients or functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those requiring a chlorohydrin or epoxy functional group.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides, where its reactive sites allow for the construction of complex heterocyclic structures.
• Polymer Modification: Serves as a monomer or cross-linking agent for specialty polymers, imparting specific properties like adhesion or chemical resistance.
• Fine Chemical Building Block: Employed in organic synthesis for the preparation of β-amino alcohols, epoxy nitriles, and other valuable chiral synthons.
• Bioconjugation Reagent: Potential use in biochemical research for modifying proteins or other biomolecules due to its electrophilic chloro group.
• Surface Active Agent Intermediate: Can be utilized in the synthesis of surfactants and emulsifiers for specialized industrial formulations.

Basic Information

Product Name	3-Chloro-2-Hydroxypropiononitrile
CAS No.	33965-80-9
Molecular Formula	C₃H₄ClNO
Molecular Weight	105.52 g/mol
Synonyms	2-Hydroxy-3-chloropropiononitrile; 3-Chloro-2-hydroxypropane nitrile; 3-Chloro-2-hydroxypropanenitrile; Chlorohydrin cyanohydrin; Glycidonitrile hydrochloride (related); 3-Chloro-2-hydroxy-propionitrile; β-Chloro-α-hydroxypropionitrile; NSC 403625
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Hydroxypropiononitrile is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including assay by HPLC and impurity profile analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Specific Gravity (20°C)	1.25 - 1.35

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.