Description

3-Acetamido-5-(2-Hydroxyethylcarbamoyl)-2,4,6-Triiodo-Benzoic Acid is a high-purity, tri-iodinated benzoic acid derivative, serving as a critical intermediate in the synthesis of modern X-ray contrast media. Its precise molecular structure is engineered to provide the necessary radiopacity and pharmacokinetic properties required for safe and effective diagnostic imaging. This compound is essential for pharmaceutical manufacturers and advanced research facilities developing next-generation non-ionic, low-osmolar contrast agents for computed tomography (CT) and angiography.

Application

• Key Intermediate for X-ray Contrast Media: Primary building block in the synthesis of iopamidol, ioversol, and other non-ionic contrast agents.
• Pharmaceutical Active Pharmaceutical Ingredient (API) Development: Used in R&D and scale-up production of novel diagnostic imaging compounds.
• Contrast Agent Research: Fundamental material for academic and industrial research into improved contrast media with enhanced safety profiles.
• Radiopharmaceutical Chemistry: Serves as a precursor in the development of iodinated compounds for various diagnostic applications.

Basic Information

Product Name	3-Acetamido-5-(2-Hydroxyethylcarbamoyl)-2,4,6-Triiodo-Benzoic Acid
CAS No.	33954-26-6
Molecular Formula	C12H11I3N2O5
Molecular Weight	651.94 g/mol
Synonyms	5-Acetamido-2,4,6-triiodo-N-(2-hydroxyethyl)isophthalamic acid; Iopamidol Intermediate; Ioversol Intermediate; 5-Acetamido-2,4,6-triiodo-N-(2-hydroxyethyl)-1,3-benzenedicarboxamide; 3-Acetamido-5-[(2-hydroxyethyl)carbamoyl]-2,4,6-triiodobenzoic acid; ATHEB Acid; Contrast Media Intermediate 33954-26-6
EINECS	Contact for details

Quality Control

Our 3-Acetamido-5-(2-Hydroxyethylcarbamoyl)-2,4,6-Triiodo-Benzoic Acid is manufactured under strict quality management systems suitable for pharmaceutical intermediate applications. Each batch is subjected to rigorous analytical testing including HPLC for purity, residual solvent analysis, and control of related substances to ensure it meets exacting standards. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere if necessary and opened only in a moisture-controlled environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.