Description

1-Bromo-3-Chloro-5-Fluorobenzene is a high-purity, multi-halogenated benzene derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to introduce halogenated aryl groups to modulate the biological activity and physical properties of target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and as anti-infective agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the halogen atoms contribute to bioactivity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating sophisticated ligands used in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and organometallic catalysts.
• Material Science: Building block for liquid crystals, organic semiconductors, and polymers requiring specific electronic properties and thermal stability.
• Chemical Research: Valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.
• Dye and Pigment Intermediate: Used in the synthesis of specialized halogenated dyes and pigments.

Basic Information

Product Name	1-Bromo-3-Chloro-5-Fluorobenzene
CAS No.	33863-76-2
Molecular Formula	C6H3BrClF
Molecular Weight	209.44 g/mol
Synonyms	3-Bromo-5-Chloro-1-Fluorobenzene; 5-Bromo-1-Chloro-3-Fluorobenzene; 3-Chloro-5-Fluorobromobenzene; 1-Fluoro-3-Chloro-5-Bromobenzene; m-Bromo-m-chloro-m-fluorobenzene; Benzene, 1-bromo-3-chloro-5-fluoro-; BCFB (abbreviation)
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Chloro-5-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high standards required for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment ensures reliable performance and batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.