Description

n-α-Z-3-Sulfamoyl-L-Alanine is a specialized, high-purity amino acid derivative featuring a sulfamoyl protecting group. This compound is a critical building block in advanced pharmaceutical research and development, particularly for the synthesis of novel peptide-based therapeutics and enzyme inhibitors. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of peptide drugs and protease inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of new active pharmaceutical ingredients (APIs).
• Bioconjugation: Serves as a modified amino acid for creating functionalized peptides and protein conjugates.
• Chemical Biology Probes: Employed in the synthesis of probes for studying enzyme mechanisms and biological pathways.
• Process Development: Used in scaling up synthetic routes for candidate drugs in preclinical and clinical stages.

Basic Information

Product Name	n-α-Z-3-Sulfamoyl-L-Alanine
CAS No.	33662-45-2
Molecular Formula	C11H14N2O6S
Molecular Weight	302.30 g/mol
Synonyms	N-Carbobenzoxy-3-sulfamoyl-L-alanine; Z-3-Sulfamoyl-L-alanine; (2S)-2-[(Benzyloxy)carbonyl]amino-3-sulfamoylpropanoic acid; N-[(Benzyloxy)carbonyl]-3-sulfamoyl-L-alanine; L-Alanine, N-[(phenylmethoxy)carbonyl]-3-(aminosulfonyl)-; 3-Sulfamoyl-L-alanine N-carboxy anhydride, Z-protected; Z-Asp(SO2NH2)-OH (common abbreviation); Benzyl N-[(1S)-1-carboxy-2-sulfamoylethyl]carbamate
EINECS	Contact for details

Quality Control

Our n-α-Z-3-Sulfamoyl-L-Alanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and a Certificate of Analysis (COA) with every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.