Description

1,3-Dioxolane, 4-(Fluoromethyl)-2,2-Dimethyl-, (S)- (9Ci) is a high-purity, chiral fluorinated building block of significant interest in advanced organic synthesis. Its value lies in its unique structure, which incorporates a protected aldehyde equivalent and a stereodefined fluoromethyl group, enabling the precise construction of complex molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of fluorinated drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the introduction of fluorine atoms enhances biological activity and environmental stability.
• Asymmetric Synthesis: Employed as a versatile, enantiomerically pure building block in stereoselective reactions to create complex molecular architectures.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced materials with tailored properties.
• Fluorine Chemistry: Serves as a valuable substrate for studying novel fluorination methodologies and C-F bond formation reactions.

Basic Information

Product Name	1,3-Dioxolane, 4-(Fluoromethyl)-2,2-Dimethyl-, (S)- (9Ci)
CAS No.	33644-24-5
Molecular Formula	C6H11FO2
Molecular Weight	134.15 g/mol
Synonyms	(S)-4-(Fluoromethyl)-2,2-dimethyl-1,3-dioxolane; (S)-2,2-Dimethyl-4-fluoromethyl-1,3-dioxolane; (S)-4-(Fluoromethyl)-2,2-dimethyl-1,3-dioxolane; (S)-1,3-Dioxolane, 4-(fluoromethyl)-2,2-dimethyl-; (S)-Glyceraldehyde Acetonide Fluoride; (S)-2,3-O-Isopropylidene-D-glyceraldehyde Fluorohydrin Acetal; Fluoromethyl Dioxolane Derivative (S)
EINECS	Contact for details

Quality Control

Our production of 1,3-Dioxolane, 4-(Fluoromethyl)-2,2-Dimethyl-, (S)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques, including chiral HPLC, GC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with every shipment to support your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details
Refractive Index	Contact for details
Density	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.