Description

3-Amino-4,4,4-trifluoro-2-butenenitrile is a versatile fluorinated organic intermediate featuring a reactive cyano group and an amino group. This compound is valued for its role as a key building block in the synthesis of complex, high-value molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought by research and development chemists and process engineers for constructing heterocyclic compounds and active ingredients. Its unique trifluoromethyl-substituted structure imparts desirable properties such as metabolic stability and lipophilicity to final products.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Fluorinated Heterocycle Construction: Serves as a starting material for creating pyrimidines, pyrazoles, and other nitrogen-containing heterocycles with fluorine substitution.
• Material Science Research: Employed in the development of specialty polymers and advanced organic electronic materials that benefit from fluorine's unique properties.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for fine chemical companies offering bespoke synthesis services for clients in life sciences.

Basic Information

Product Name	3-Amino-4,4,4-trifluoro-2-butenenitrile
CAS No.	33561-24-9
Molecular Formula	C5H3F3N2
Molecular Weight	148.09 g/mol
Synonyms	4,4,4-Trifluoro-3-aminocrotononitrile; 3-Amino-4,4,4-trifluorobut-2-enenitrile; (Z)-3-Amino-4,4,4-trifluorobut-2-enenitrile; 3-Amino-4,4,4-trifluoro-2-butenenitrile; 2-Butenenitrile, 3-amino-4,4,4-trifluoro-; 3-Amino-4,4,4-trifluorocrotononitrile; TFACN; ATFBN
EINECS	Contact for details

Quality Control

Our 3-Amino-4,4,4-trifluoro-2-butenenitrile is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.