Description

Substance P CAS NO 33507-63-0 is an undecapeptide neuropeptide belonging to the tachykinin family, acting as a key neurotransmitter and neuromodulator. Its primary value lies in its potent biological activity, mediating pain perception, neurogenic inflammation, and smooth muscle contraction. This makes it an essential research tool for neuroscientists, pharmacologists, and biochemists in academic, pharmaceutical, and biotechnology sectors.

Application

• Neuroscience Research: Fundamental studies on pain pathways, neurogenic inflammation, and the role of tachykinins in the central and peripheral nervous systems.
• Drug Discovery & Pharmacology: Used as a standard and tool compound for screening and developing novel NK1 receptor antagonists for pain, migraine, and emesis.
• Cell Biology & Signaling: Investigation of G-protein coupled receptor (GPCR) signaling, calcium mobilization, and cellular excitability in various cell lines.
• Inflammation & Immunology: Research into neuroimmune interactions, mast cell degranulation, and cytokine release.
• Physiological Studies: Exploring its role in gastrointestinal motility, salivary secretion, and bronchoconstriction.
• Biochemical Assay Development: Serving as a critical component in ELISA, RIA, and functional bioassays to quantify activity or receptor binding.

Basic Information

Product Name	Substance P
CAS No.	33507-63-0
Molecular Formula	C63H98N18O13S
Molecular Weight	1347.63 g/mol
Synonyms	Substance P (human, bovine, canine, guinea pig, mouse, pig, rabbit, rat); Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2; H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2; SP; Neurokinin P; Tachykinin, mammalian; Substance P acetate salt; Substance P free base
EINECS	Contact for details

Quality Control

Our Substance P is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to rigorous quality testing protocols, and custom synthesis to specific purity grades (e.g., >95%, >98%) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting to avoid repeated freeze-thaw cycles. Allow the vial to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	Contact for details
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.