Description

1-Bromo-2-(4-Methylphenyl)Acetylene is a versatile and high-value halogenated aromatic alkyne building block, essential for advanced organic synthesis. Its core value lies in enabling efficient cross-coupling reactions, such as Sonogashira and Suzuki couplings, to construct complex molecular architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, including kinase inhibitors and other biologically active molecules.
• Agrochemical Research: Used in constructing novel pesticide and herbicide scaffolds through palladium-catalyzed coupling reactions.
• Material Science & OLED Development: Serves as a precursor for creating conjugated polymers and small-molecule organic semiconductors for electronic devices.
• Ligand & Catalyst Synthesis: Employed in the preparation of specialized phosphine or N-heterocyclic carbene ligands for catalysis.
• Chemical Biology & Probe Development: Useful for incorporating alkyne handles into molecules for bioorthogonal labeling (e.g., click chemistry) in proteomics and cellular imaging.
• Academic & Contract Research: A valuable reagent for methodological development and exploring new synthetic pathways in university and CRO laboratories.

Basic Information

Product Name	1-Bromo-2-(4-Methylphenyl)Acetylene
CAS No.	33491-05-3
Molecular Formula	C9H7Br
Molecular Weight	195.06 g/mol
Synonyms	1-Bromo-2-(p-tolyl)acetylene; 2-(4-Methylphenyl)ethynyl bromide; p-Tolylethynyl bromide; 4-Methylphenylethynyl bromide; (4-Methylphenyl)ethynyl bromide; 1-Bromo-2-(4-methylphenyl)ethyne; Bromo(4-methylphenyl)acetylene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(4-Methylphenyl)Acetylene is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality systems support development from research to commercial scale, ensuring reliable supply for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.