Description

1-Bromo-2-(4-Chlorophenyl)Acetylene is a versatile halogenated aromatic acetylene building block of significant importance in advanced organic synthesis. This compound matters because it serves as a critical intermediate for constructing complex molecular architectures, particularly in the development of pharmaceuticals and agrochemicals. Researchers and process chemists in the pharmaceutical, agrochemical, and material science industries need it for applications such as Sonogashira cross-coupling reactions and the synthesis of bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing diaryl acetylene motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides that require specific halogenated aromatic structures.
• Material Science: Serves as a monomer or precursor in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An essential substrate for palladium-catalyzed Sonogashira, Heck, and other cross-coupling reactions to form carbon-carbon bonds.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries.
• Ligand Preparation: Used to synthesize specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Bromo-2-(4-Chlorophenyl)Acetylene
CAS No.	33491-03-1
Molecular Formula	C8H4BrCl
Molecular Weight	215.47 g/mol
Synonyms	1-Bromo-4-chlorophenylethyne; (4-Chlorophenyl)ethynyl bromide; 4-Chlorophenylacetylene bromide; 2-Bromo-1-(4-chlorophenyl)ethyne; 1-Bromo-2-(p-chlorophenyl)acetylene; p-Chlorophenyl ethynyl bromide; 4-Chlorobenzeneacetylene bromide
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(4-Chlorophenyl)Acetylene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.