Description

3,3-Difluorooxetane CAS NO 33420-50-7 is a highly versatile fluorinated heterocyclic building block, prized for its ability to introduce the oxetane ring and fluorine atoms into advanced molecular architectures. This compound is critical for enhancing the physicochemical properties of target molecules, such as metabolic stability, lipophilicity, and bioavailability. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for incorporating the metabolically stable oxetane moiety into drug candidates, particularly in medicinal chemistry for oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides where fluorine substitution improves activity and environmental profile.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating fluorinated polymers with unique surface properties, chemical resistance, and low dielectric constants.
• Liquid Crystal & OLED Materials: Employed in the synthesis of fluorinated components for electronic displays and organic light-emitting diodes to optimize performance and stability.
• Lithography & Photoresists: Acts as a precursor in the manufacture of advanced photoresists for semiconductor fabrication, leveraging its etching resistance.
• Organic Synthesis Building Block: Utilized in academic and industrial R&D for ring-opening reactions, nucleophilic substitutions, and as a scaffold for library synthesis.

Basic Information

Product Name	3,3-Difluorooxetane
CAS No.	33420-50-7
Molecular Formula	C3H4F2O
Molecular Weight	94.06 g/mol
Synonyms	3,3-Difluorooxetane; 3,3-Difluorooxacyclobutane; 3,3-Difluoro-1-oxacyclobutane; Oxetane, 3,3-difluoro-; 1-Oxa-3,3-difluorocyclobutane; DFOX; 3,3-Difluorooxetane homopolymer
EINECS	Contact for details

Quality Control

Every batch of 3,3-Difluorooxetane is produced and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as purity, identity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its highly volatile nature, keep containers tightly sealed and handle in a fume hood. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.