Description

H-Thr-Nh2 Hcl is a high-purity, protected amino acid derivative, specifically the hydrochloride salt of L-Threonine amide. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the precise construction of complex molecular architectures. It is essential for research and production in the pharmaceutical, biotechnology, and peptide synthesis industries, where it is used to develop novel therapeutics and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral and anticancer drug development.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected threonine derivative to construct specific peptide sequences.
• Bioconjugation & Linker Chemistry: Employed in the design and synthesis of antibody-drug conjugates (ADCs) and other bioconjugates due to its reactive amine handle.
• Proteomics Research: Utilized as a standard or reagent in mass spectrometry and other analytical techniques for protein and peptide analysis.
• Chemical Biology: Serves as a building block for creating chemical probes and inhibitors to study enzyme function and biological pathways.
• Custom Synthesis: A starting material for the custom synthesis of complex organic molecules, natural products, and specialty chemicals.

Basic Information

Product Name	H-Thr-Nh2 Hcl
CAS No.	33209-01-7
Molecular Formula	C4H11ClN2O2
Molecular Weight	154.60 g/mol
Synonyms	L-Threoninamide hydrochloride; (2S,3R)-2-Amino-3-hydroxybutanamide hydrochloride; H-Thr-NH2·HCl; Thr-NH2 HCl; Threonine amide hydrochloride; 2-Amino-3-hydroxybutyramide hydrochloride; (2S,3R)-Threoninamide hydrochloride; Fmoc-Thr-NH2 HCl (when referring to the protected form)
EINECS	Contact for details

Quality Control

Our H-Thr-Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm
Solubility	Clear, colorless solution in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.