Description

Boc-p-Azido-Phe-Oh CAS NO 33173-55-6 is a protected amino acid derivative featuring a p-azidophenylalanine backbone with a tert-butoxycarbonyl (Boc) protecting group on the amine. This compound is a critical building block in peptide synthesis and bioorthogonal chemistry, enabling the site-specific introduction of azide functional groups for subsequent click chemistry reactions like the Staudinger ligation or copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and the creation of antibody-drug conjugates (ADCs) and other bioconjugates who require precise chemical modification of peptides and proteins.

Application

• Peptide Synthesis: Serves as a key intermediate for incorporating azide handles into custom peptide sequences during solid-phase or solution-phase synthesis.
• Bioconjugation & ADC Development: Enables the site-specific labeling of proteins, antibodies, and other biomolecules via click chemistry for the creation of targeted therapeutics and diagnostics.
• Chemical Biology & Proteomics: Used in activity-based protein profiling (ABPP) and the study of protein-protein interactions through bioorthogonal tagging strategies.
• Material Science & Surface Functionalization: Facilitates the modification of polymers, nanoparticles, and surfaces with bioactive peptides for biomedical and sensor applications.
• Library Synthesis: A valuable scaffold for generating diverse chemical libraries in drug discovery programs focused on peptide mimetics.

Basic Information

Product Name	Boc-p-Azido-Phe-Oh
CAS No.	33173-55-6
Molecular Formula	C₁₄H₁₈N₄O₄
Molecular Weight	306.32 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-4-azido-L-phenylalanine; Boc-4-azido-L-phenylalanine; Boc-Azido-Phe-OH; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(4-azidophenyl)propanoic acid; N-Boc-L-4-azidophenylalanine; tert-Butyl (2S)-2-amino-3-(4-azidophenyl)propanoate; Boc-p-azido-L-Phe-OH; Nα-Boc-4-azido-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Boc-p-Azido-Phe-Oh is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation. The material is light-sensitive and easily oxidized; allow it to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Specific Rotation	-10.0° to -15.0° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.