Description

7-Hydroxyfluphenazine is a key pharmaceutical intermediate and metabolite of the antipsychotic agent fluphenazine. This compound is of significant importance in the research, development, and quality control of neuroleptic medications. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in drug metabolism studies, impurity profiling, and reference standard preparation.

Application

• Pharmaceutical Intermediate: Critical synthesis building block for the production of fluphenazine and related phenothiazine derivatives.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical labs.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism and biological activity of fluphenazine.
• Impurity Profiling: Serves as a known impurity standard to monitor and control the quality of active pharmaceutical ingredients (APIs) and finished drug products.
• Biochemical Research: Employed in neuroscience and psychiatric research to investigate the mechanisms of action of antipsychotic drugs.

Basic Information

Product Name	7-Hydroxyfluphenazine
CAS No.	33098-48-5
Molecular Formula	C₂₂H₂₆F₃N₃OS
Molecular Weight	437.52 g/mol
Synonyms	7-Hydroxyfluphenazine; 2-[4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazinyl]ethanol; Fluphenazine 7-Hydroxy Metabolite; Fluphenazine 7-OH; 1-[3-[2-(Trifluoromethyl)phenothiazin-10-yl]propyl]-4-(2-hydroxyethyl)piperazine; 10-[3-[4-(2-Hydroxyethyl)piperazin-1-yl]propyl]-2-(trifluoromethyl)-10H-phenothiazin-7-ol
EINECS	Contact for details

Quality Control

Our 7-Hydroxyfluphenazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.