Description

n-Pivaloyl-L-Tyrosine is a high-purity, protected amino acid derivative where the tyrosine side chain is shielded by a pivaloyl group. This compound is a critical building block in peptide synthesis and pharmaceutical research, offering enhanced stability and controlled reactivity. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic peptides and active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: A key intermediate in solid-phase and solution-phase peptide synthesis for incorporating tyrosine residues with a protected phenolic hydroxyl group.
• Pharmaceutical Research: Used in the research and development of peptide-based drugs, hormones, and diagnostic agents.
• Bioconjugation: Serves as a modified amino acid for creating custom peptide conjugates and labeled biomolecules.
• Chemical Biology: Employed in studying enzyme-substrate interactions and protein structure-function relationships.
• Fine Chemical Intermediate: Acts as a precursor for more complex chiral molecules and specialty chemicals.

Basic Information

Item	Details
Product Name	n-Pivaloyl-L-Tyrosine
CAS No.	33019-85-1
Molecular Formula	C₁₄H₁₉NO₄
Molecular Weight	265.31 g/mol
Synonyms	L-Tyrosine, N-pivaloyl-; Pivaloyl-L-tyrosine; (2S)-2-[(2,2-Dimethylpropanoyl)amino]-3-(4-hydroxyphenyl)propanoic acid; N-(2,2-Dimethyl-1-oxopropyl)-L-tyrosine; Boc-L-Tyrosine(Piv)-OH (Note: This is a common related derivative); N-tert-Butoxycarbonyl-L-tyrosine O-pivalate; Fmoc-L-Tyrosine(Piv)-OH (Note: This is a common related derivative)
EINECS	Contact for details

Quality Control

Our n-Pivaloyl-L-Tyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. We provide Certificates of Analysis (COA) with detailed specifications for traceability and quality assurance, supporting cGMP-compliant applications where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: Specific range available on COA
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.