Description

(2S)-2-(2,2-Dimethylpropanamido)-4-Methylpentanoic Acid is a high-purity, non-natural amino acid derivative, specifically a pivaloyl-protected L-leucine analog. This compound is a critical chiral building block and intermediate in the synthesis of complex pharmaceutical molecules, particularly peptides and peptidomimetics. It is essential for research and development chemists in the pharmaceutical, biotechnology, and fine chemical sectors who require high-quality, stereochemically pure intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for metabolic and cardiovascular drugs.
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis to introduce the leucine residue with a bulky, base-labile protecting group.
• Protease Inhibitor Development: Serves as a core structural component in the design and development of protease inhibitors due to its specific stereochemistry and side chain.
• Bioconjugation & Labeling: Acts as a linker or spacer molecule in bioconjugation chemistry for attaching drugs, dyes, or other functionalities to biomolecules.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms as a modified amino acid probe.
• Asymmetric Synthesis Catalyst: Can be utilized as a precursor or ligand in the development of chiral catalysts for asymmetric transformations.

Basic Information

Product Name	(2S)-2-(2,2-Dimethylpropanamido)-4-Methylpentanoic Acid
CAS No.	33019-84-0
Molecular Formula	C11H21NO3
Molecular Weight	215.29 g/mol
Synonyms	L-Leucine, N-pivaloyl-; Pivaloyl-L-leucine; N-(2,2-Dimethyl-1-oxopropyl)-L-leucine; (S)-2-(2,2-Dimethylpropanamido)-4-methylpentanoic acid; N-Pivaloyl-L-leucine; N-tert-Butylcarbonyl-L-leucine; Boc-Leucine analog; 33019-84-0; L-Leu-Piv
EINECS	Contact for details

Quality Control

Our (2S)-2-(2,2-Dimethylpropanamido)-4-Methylpentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.