Description

4-(Trifluoromethyl)Phenylacetic Acid is a versatile fluorinated aromatic building block characterized by its phenylacetic acid core substituted with a trifluoromethyl group. This structural motif is highly valued for its ability to impart enhanced metabolic stability, lipophilicity, and bioavailability to target molecules, making it a critical intermediate in advanced synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in non-steroidal anti-inflammatory drugs (NSAIDs) and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the CF₃ group enhances biological activity.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Synthesis Building Block: Employed in coupling reactions (e.g., Suzuki, Heck) and as a precursor for esters, amides, and other derivatives in fine chemical manufacturing.
• Material Science Research: Utilized in the development of novel polymers and advanced organic materials with specific electronic or surface properties.

Basic Information

Product Name	4-(Trifluoromethyl)Phenylacetic Acid
CAS No.	32857-62-8
Molecular Formula	C₉H₇F₃O₂
Molecular Weight	204.15 g/mol
Synonyms	2-[4-(Trifluoromethyl)phenyl]acetic Acid; (4-Trifluoromethylphenyl)acetic Acid; α-(4-Trifluoromethylphenyl)acetic Acid; 4-(Trifluoromethyl)benzeneacetic Acid; p-(Trifluoromethyl)phenylacetic Acid; 4-CF₃-Phenylacetic Acid; 4-Trifluoromethylbenzeneacetic Acid
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Phenylacetic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	108°C - 112°C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.