Description

3-[[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Thio]Methyl]-7β-[[(R)-Aminophenylacetyl]Amino]Cepham-3-Ene-4-Carboxylic Acid is a key advanced pharmaceutical intermediate in the synthesis of modern cephalosporin antibiotics. Its value lies in its role as a critical building block for constructing potent, broad-spectrum antibacterial agents with enhanced stability against β-lactamases. This compound is essential for pharmaceutical manufacturers and R&D facilities focused on developing and producing next-generation antibiotic therapies to address resistant bacterial infections.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a high-value intermediate in the multi-step synthesis of third and fourth-generation cephalosporin antibiotics.
• Pharmaceutical Research & Development: Serves as a crucial scaffold for medicinal chemists exploring novel β-lactam structures and structure-activity relationships (SAR).
• Antibiotic Manufacturing: Integral component in the commercial-scale production of specific, potent cephalosporin drugs targeting resistant pathogens.
• Biochemical Studies: Used in research to study bacterial resistance mechanisms and the interaction between β-lactam compounds and penicillin-binding proteins (PBPs).

Basic Information

Product Name	3-[[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Thio]Methyl]-7β-[[(R)-Aminophenylacetyl]Amino]Cepham-3-Ene-4-Carboxylic Acid
CAS No.	32832-19-2
Molecular Formula	C19H21N5O4S2
Molecular Weight	447.53 g/mol
Synonyms	(6R,7R)-7-[[(2R)-Amino(2-phenylacetyl)amino]]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7β-[(R)-2-Amino-2-phenylacetamido]-3-[(5-methyl-1,3,4-thiadiazol-2-ylthio)methyl]ceph-3-em-4-carboxylic acid; Cephalosporin C derivative intermediate; 3-[(5-Methyl-1,3,4-thiadiazol-2-ylthio)methyl]-7β-[(R)-2-phenylglycylamino]ceph-3-em-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-[[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Thio]Methyl]-7β-[[(R)-Aminophenylacetyl]Amino]Cepham-3-Ene-4-Carboxylic Acid is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistent quality and traceability. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.