Description

Lorazepam Glucuronide is the primary inactive metabolite of the benzodiazepine drug lorazepam, formed via glucuronidation in the liver. This reference standard is critical for pharmaceutical research and development, enabling precise analytical studies of drug metabolism and pharmacokinetics. It is an essential material for laboratories in the pharmaceutical, forensic toxicology, and clinical diagnostics sectors, particularly for those developing and validating bioanalytical methods.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantitative and qualitative analysis of lorazepam and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Crucial for investigating the metabolic pathways, clearance rates, and bioavailability of lorazepam in preclinical and clinical research.
• Forensic and Clinical Toxicology: Used to calibrate equipment and validate methods for accurately detecting and quantifying lorazepam exposure in urine, blood, or plasma samples.
• Bioanalytical Method Development: Serves as a key analyte for developing and validating high-performance liquid chromatography (HPLC), LC-MS/MS, and other chromatographic assays.
• Impurity Profiling: Employed in the quality control of active pharmaceutical ingredients (APIs) to identify and quantify related substances and degradation products.
• Regulatory Submissions: Provides essential data to support regulatory filings with agencies like the FDA and EMA by demonstrating accurate metabolite tracking.

Basic Information

Product Name	Lorazepam Glucuronide
CAS No.	32781-79-6
Molecular Formula	C22H23ClN2O8
Molecular Weight	478.88 g/mol
Synonyms	Lorazepam β-D-Glucuronide; Lorazepam Glucuronide; 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one 3-β-D-Glucopyranosiduronic Acid; 3-O-(β-D-Glucopyranosyluronic acid)lorazepam; Lorazepam 3-Glucuronide; Lorazepam Metabolite; LOR-glu; UNII-6V7V7B1Z6I
EINECS	Contact for details

Quality Control

Our Lorazepam Glucuronide is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for use as an analytical reference standard. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated methods such as HPLC and NMR. We adhere to relevant industry best practices for pharmaceutical impurities and metabolites. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. For long-term storage, consider storing desiccated at -20°C. Keep the container sealed to protect this moisture-sensitive compound from humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.